Tranexamic acid for traumatic hemorrhage.
نویسندگان
چکیده
TBE-CiTE Journal Club: January 17, 2012, with the participation of the following institutions: Trauma Research Program of the Department of Surgery of the Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada; Division of Trauma Surgery, University of Campinas, Campinas, Brazil. 1.Fellow, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada; 2. Professor, Department of Surgery and Anatomy, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil; 3. Associate Professor, Department of Surgery & Critical Care, University of Toronto, Toronto, Canada; 4. Professor and Coordinator, Division of Trauma Surgery, University of Campinas, Campinas, Brazil; 5. Assistant Professor (c), Department of Surgery, University of Toronto, Toronto, Canada. INTRODUCTION
منابع مشابه
The role of tranexamic acid (Cyklokapron) in the treatment of traumatic hyphaema.
Thirty-five patients with traumatic hyphaema were studied. One group of 18 was treated routinely and the other group of 17 was treated additionally with cyklokapron (tranexamic acid) orally. Patients with other serious ocular injuries were excluded. The incidenceofsecondary haemorrhage, speed of recovery and the final visual acuity were noted. It was found that the majority of patients treated ...
متن کامل[Tranexamic acid therapy decreases mortality of traumatic hemorrhagic shock].
The CRASH 2, a randomized, double-blind, controlled trial, that enrolled 20,211 adult trauma patients, has shown that the administration of tranexamic acid significantly reduces all-cause mortality and that specifically associated with severe blood loss as well. We consider it a significant therapeutic advance, because, for the first time, a drug has been demonstrated to safely diminish mortali...
متن کاملComparison between Topical and Oral Tranexamic Acid in Management of Traumatic Hyphema
Background: We sought to determine the efficacy of topical tranexamic acid (5%) in the management of traumatic hyphema.Methods: Thirty eyes with gross traumatic hyphema were enrolled in this study. The patients were treated with tranexamic acid (5%) eye drop every 6 hours for 5 days. The main outcome measures were best corrected visual acuity (BCVA), Intra-ocular pressure (IOP), day of clot abs...
متن کاملImpact of Intravenous Tranexamic Acid on Hemorrhage During Endoscopic Sinus Surgery
Introduction: Endoscopic sinus surgery is a common procedure performed by otolaryngologists. This study evaluated the efficacy of intravenous (IV) tranexamic acid (TA) on hemorrhage in patients undergoing elective endoscopic sinus surgery (ESS). Materials and Methods: The present study was performed in 170 patients scheduled for ESS surgery under general anesthesia in order to examine the ef...
متن کاملTranexamic acid to reduce postpartum hemorrhage: A MANDATE systematic review and analyses of impact on maternal mortality.
OBJECTIVE Postpartum hemorrhage (PPH) is a major cause of maternal mortality, with almost 300,000 cases and ~72,000 PPH deaths annually in sub-Saharan Africa. Novel prevention methods practical in community settings are required. Tranexamic acid, a drug to reduce bleeding during surgical cases including postpartum bleeding, is potentially suitable for community settings. Thus, we sought to dete...
متن کاملEffect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study)
Objective To assess the effect of tranexamic acid (which reduces bleeding in surgical patients and reduces mortality due to bleeding in trauma patients) on intracranial haemorrhage in patients with traumatic brain injury. Methods A nested, randomised, placebo controlled trial. All investigators were masked to treatment allocation. All analyses were by intention to treat. Patients 270 adult trau...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Revista do Colegio Brasileiro de Cirurgioes
دوره 39 1 شماره
صفحات -
تاریخ انتشار 2012